Journal article

Abortive replication of influenza virus in mouse dendritic cells

LJ Ioannidis, EE Verity, S Crawford, SP Rockman, LE Brown

Journal of Virology | Published : 2012

DOI: 10.1128/JVI.07060-11

Abstract

The interaction between influenza virus and dendritic cells (DCs) remains poorly defined and controversial. Here we show that influenza virus replication in mouse bone marrow-derived DCs is abortive, despite viral genome transcription and replication occurring for each gene segment and viral hemagglutinin and nucleoprotein, at least, being produced. Electron microscopy reveals that virus assembly, rather than release of virus from the cell surface, is defective. © 2012, American Society for Microbiology.

University of Melbourne Researchers

Lorena Brown Author

Related Projects (3)

UNDERSTANDING AND CONTROLLING INFLUENZA

While current influenza vaccines blunt winter epidemics, they must be updated frequently to keep up with virus mutation and they do not prot..

UNDERSTANDING AND CONTROLLING INFLUENZA

While current influenza vaccines blunt winter epidemics, they must be updated frequently to keep up with virus mutation and they do not prot..

How influenza spreads within the body

We are exploring how influenza virus moves down the respiratory tract after infecting the nose. We have identified a component of mouse sali..

Grants

Awarded by National Health and Medical Research Council of Australia

Funding Acknowledgements

This work was supported by project grant 509281 and program grant 567122 from the National Health and Medical Research Council of Australia.

Citation metrics

31Web of Science

Keywords

31 Biological Sciences

2.2 Factors Relating To the Physical Environment

Infectious Diseases

3107 Microbiology

Pneumonia & Influenza

Science & Technology

Emerging Infectious Diseases

Life Sciences & Biomedicine

3207 Medical Microbiology

32 Biomedical and Clinical Sciences